Take the show South Park. While you may not always agree with the message, you will usually remember it due to the direct way that the story was told.
As an example, anyone who has ever watched the South Park episode on Scientology will never forget it (if you never saw it you can watch it here).
While the cartoons below are more sad (for the country) than funny, they convey a clear and concise message!
Don't ever miss a thing!